Charles Peirce is widely credited as the originator of semiotics, or the general theory of signs, and recognized as the founder of American pragmatism, albeit in that peculiar kind Peirce himself went on to distinguish as “pragmaticism.” The semiotic and pragmatist strands in Peirce’s thought come together in an appraisal of scientific diagrammatic representations. Peirce’s pragmatic maxim entails that the consequences of a sign inform our entire conception of the sign, while his most considered semiotic system entails that a complex (...) sign partakes of iconic, indexical, and symbolic aspects. We illustrate Peirce’s insights by means of the celebrated Feynman Diagrams in Quantum Electrodynamics. We argue that Peirce’s late, post-1903, semiotics provides an adequate characterization of such “hypoicons,” and his pragmatic maxim explains how they can motivate and drive inquiry. We conclude that Peirce’s pragmatic approach to scientific diagrams remains a viable position that skillfully avoids dogmatic scientism and nihilistic skepticism alike. (shrink)

¿Es posible proponer una teología que ignore el dinamis­mo del deseo humano? Lo que en otros tiempos pudo ser objeto de sos­pecha se presenta en este occidente hastiado de promesas incumplidas como oportunidad para recordar al hombre la respuesta a la pregunta que él mismo es. El deseo remite a Dios, como veremos, pero el mismo Dios educa ese deseo humano desde la pedagogía de la promesa. Unapedagogía a la que no fue ajeno Jesús, que se ejemplifica en la vida (...) deMaría y de la Iglesia, que la Iglesia actualiza en los sacramentos y quemodela la esperanza final. (shrink)

This article proposes a guideline to develop an ontology of software. The first section gives a brief introduction to the importance of such ontology as a possible conceptual grounding for the philosophy of software, philosophy of computing and philosophy of information. The second section presents the background of the scope of this article in terms of both a symbolic and materialistic approach to software. The third section deploys the basic guidelines with the expositions of the two dimensions of software: the (...) serial dimension and the structural dimension. The first dimension consists of three series, while the second in the exposition of the structure of any program. The fourth and last section will deal with a better understanding of what we can call the digital universe. (shrink)

El ejercicio de la jurisdicción universal permite a los estados cubrir la falta de competencia de la Corte Penal Internacional para la persecución de los crímenes que se están cometiendo en el contexto de la guerra en Ucrania y, en general, en cualquier lugar del mundo. Pero dos años después de la invasión de Rusia en el este del país y diez desde la ocupación del sur, las iniciativas en este sentido han partido desde estados europeos, entre la escasa implicación (...) de América Latina. No pocos sistemas penales americanos contemplan en su legislación nacional la posibilidad de aplicar la jurisdicción universal y hasta la Corte Interamericana de Derechos Humanos ha defendido recientemente este principio. La persecución de los crímenes internacionales interesa a toda la comunidad internacional, pero América Latina no se ha movilizado ante la extraordinaria gravedad de los sucesos en Ucrania. (shrink)

This paper describes a scenario-based methodology called the NeOn Methodology framework. The aim of this framework is to speed up the construction of ontologies and ontology networks by reu...

Children learning to read in two different orthographic systems are exposed to cross-linguistic interferences. We explored the effects of school and grade on phonological activation during a visual word recognition task. Elementary school children from Spain completed a lexical decision task in English. The task included real words and pseudohomophones following Spanish or English phonological rules. Using the mouse-tracking paradigm, we analyzed errors, reaction times, and computer mouse movements. Children in the bilingual school performed better than children in the monolingual (...) school. Children in higher grades performed better than children in lower grades. The interference effect of Spanish phonology was weak and became weaker in higher grades. Spanish children differentiate between first and second language grapheme-to-phoneme correspondences since early on in the educational process. In 6th grade, children from the bilingual school responded better to words and Spanish pseudohomophones, while children from the monolingual school were less distracted by the English pseudohomophones. Children in the bilingual school had stronger inhibition of Spanish phonology and stronger activation of English phonology. Instructional method plays an important role on the processing strategies Spanish children rely on when reading in English. School and grade influence the link between orthographic and phonological representations. (shrink)

Cardiology is characterized by its state-of-the-art biomedical technology and the predominance of Evidence-Based Medicine. This predominance makes it difficult for healthcare professionals to deal with the ethical dilemmas that emerge in this subspecialty. This paper is a first endeavor to empirically investigate the axiological foundations of the healthcare professionals in a cardiology hospital. Our pilot study selected, as the target population, cardiology personnel not only because of their difficult ethical deliberations but also because of the stringent conditions in which they (...) have to make them. Therefore, there is an urgent need to reconsider clinical ethics and Value-Based Medicine. This study proposes a qualitative analysis of the values and the virtues of healthcare professionals in a cardiology hospital in order to establish how the former impact upon the medical and ethical decisions made by the latter. (shrink)

IntroductionCardiology is characterized by its state-of-the-art biomedical technology and the predominance of Evidence-Based Medicine. This predominance makes it difficult for healthcare professionals to deal with the ethical dilemmas that emerge in this subspecialty. This paper is a first endeavor to empirically investigate the axiological foundations of the healthcare professionals in a cardiology hospital. Our pilot study selected, as the target population, cardiology personnel not only because of their difficult ethical deliberations but also because of the stringent conditions in which they (...) have to make them. Therefore, there is an urgent need to reconsider clinical ethics and Value-Based Medicine. This study proposes a qualitative analysis of the values and the virtues of healthcare professionals in a cardiology hospital in order to establish how the former impact upon the medical and ethical decisions made by the latter.ResultsWe point out the need for strengthening the roles of healthcare personnel as educators and guidance counselors in order to meet the ends of medicine, as well as the need for an ethical discernment that is compatible with our results, namely, that the ethical values developed by healthcare professionals stem from their life history as well as their professional education.ConclusionWe establish the kind of actions, communication skills and empathy that are required to build a stronger patient-healthcare professional relationship, which at the same time improves prognosis, treatment efficiency and therapeutic adhesion. (shrink)

After compulsory secondary education; many teenagers face the process of choosing a university degree. This process involves uncertainties referred to their personal abilities, interests, social expectations and professional future. The present work is aimed at determining whether the reasons behind the selection of a particular university degree differ depending on the chosen degree. Another objective is determining whether these reasons differ significantly according to gender. The sample comprises 983 students belonging to the area of social and legal sciences at the (...) University of Seville. The obtained results reveal the existence of four main reasons behind the selection of university degrees for which significant gender-related differences were observed: easy degree, job opportunities, high wages and provision of social services. Besides, these seven reasons are observed to differ widely in six of the considered degrees. (shrink)

La tesis central de este estudio puede resumirse así: el estado-nación, como forma histórica del estado, adolece de falta de adecuación con el modelo de estado democrático y de derecho, tal como fue formulado por la tradición liberal-republicana. Para mostrar esta falta de adecuación, el estudio expone primero los axiomas del paradigma republicano. Se definen después los conceptos de universalidad, ciudadanía y nacionalidad. Y se describen, por fin, las operaciones ideológicas modernas que han unificado los conceptos de pueblo y nación, (...) por un lado, y de nación y estado, por otro. (shrink)

Este trabajo intenta analizar la concepción, naturaleza jurídica y garantía de los derechos económicos, sociales y culturales, en América Latina, así como las condiciones y medidas que pueden contribuir a su efectividad. Presenta también una propuesta de indicadores que pueden utilizarse en la supervisión de la efectividad de esos derechos y de la protección que ellos han alcanzado, proporcionando información sobre la situación latinoamericana y caribeña actual.

Resumen: En este artículo reviso la interpretación de Eduardo Nicol de la teoría de la propiedad de Francisco Suárez. Para ello, presento la posición de Suárez acerca de la propiedad y la propiedad privada atendiendo dos cuestiones fundamentales. La primera es si la propiedad y la propiedad privada son derechos; la segunda es si ambos pertenecen a la naturaleza humana o no. Al final, argumento que la lectura de Nicol es insostenible, pues difícilmente puede admitirse que Suárez (...) defendió algún tipo de comunismo.: In this paper I revisit Eduardo Nicol’s interpretation of Suarez’s theory of property. To this purpose, I present Suárez’s account of property and private property focusing on two main aspects. The first is whether property and private property are rights; the second is whether they belong to the human nature or not. Finally, I argue that Nicol’s reading of Suárez is untenable for it can hardly be accepted that Suárez defended some kind of communism. (shrink)

El actual Derecho Penal de la seguridad que se expresa en el populismo punitivo tiene un sesgo orientado a la persecución penal de los delitos callejeros, violentos, mientras que los delitos del poder y los negocios discurre con mayor tolerancia de la sociedad y de los operadores jurídicos, porque se realizan en contextos normalizados. Para sustentar esta tesis, se analiza qué entiende mayoritariamente la sociedad por delincuencia grave, la visibilidad de los delitos y las estadísticas criminales, principalmente. Este análisis nos (...) lleva a la consideración de que la percepción del daño social, el miedo a ser víctimas de delitos, la tolerancia social hacia determinados comportamientos, los medios de comunicación que construyen estereotipos, la visibilidad que se muestra en las estadísticas, todo ello conjugado, da lugar a una construcción social del contenido material de delincuencia grave de manera selectiva, orientado hacia los delitos contra las personas, dejando fuera de foco los delitos socioeconómicos. (shrink)

Este trabajo intenta analizar la concepción, naturaleza jurídica y garantía de los derechos económicos, sociales y culturales, en América Latina, así como las condiciones y medidas que pueden contribuir a su efectividad. Presenta tambien una propuesta de indicadores que pueden utilizarse en la supervision de la efectividad de esos derechos y de la proteccion que ellos han alcanzado, proporcionando información sobre la situactón latinoamericana y caribeña actual.

The most popular work of Francisco Sánchez, Quo nihil scitur (1581), transmits an absolutely sceptic thought. However, other writings like Carmen de Cometa anni M.D.LXXVII (1578), offer us different ideas about how Sánchez considers possible the scientific knowledge like, for example, his idea about the casual relations between natural objects.

Recordar y conmemorar a José Luis Serrano nos exige hacer balance de su dimensión de profesor, escritor, investigador y político, aspectos de su persona que no siempre son fáciles de delimitar, pues desde sus inicios académicos, el conocimiento científico, la política y la cultura se encuentran estrechamente ligados. Creo que entenderemos mejor al hombre y académico-docente si utilizamos sus propias palabras, contenidas en su autobiografía. Él mismo reconocía que toda biografía, o autobiografía, es un género literario, y que el (...) mismo acto de escribir es una forma de hacer autobiografía cifrada…. (shrink)

El presente trabajo resume y comenta algunas de las aportaciones que nos han parecido más relevantes realizadas en los últimos años en torno a la obra filosófica de J. Ortega y Gasset. Desde la aparición del libro de P. Cerezo Galán La voluntad de aventura en 1983, el interés por el problema de Ortega ha experimentado un auge muy significativo y creciente en España, del que son muestra los estudios de Javier San Martín, Mª Carmen Paredes, Fco J. Martín, (...) Máximo Martín Serrano y Jaime de Salas. Nuestro trabajo, tras una exposición resumida de estas interpretaciones, intenta una síntesis conciliadora que creemos sugerida por los propios textos del filósofo. (shrink)

The current times call for reforms in educational processes. The Covid-19 pandemic had an unforeseen impact on the educational system in all countries. This need for change requires new pedagogies and new methods for teaching and learning. Understanding the need for change is essential for the formulation of adaptive proposals, as well as for the generation of training activities to complement the teaching curriculum. New educational practices lead to a vision of educational quality, with new approaches that allow the continuous (...) integration of knowledge and permanent interaction with the student. This paper presents an analysis of the new teaching methodologies in times of confinement due to the pandemic caused by Covid-19. Keywords: Teaching methodologies, educational system, learning process. References [1]É. Tremblay-Wragg, C. Raby, L. Ménard y I. Plante, «El uso de estrategias didácticas diversificadas por cuatro profesores universitarios: ¿qué contribución a la motivación de aprendizaje de sus alumnos?,» Docencia en educación superior, vol. 26, nº 21, 2021. [2]L. Czerniewicz, R. Mogliacci, S. Walji, A. Cliff, B. Swinnerton y N. Morris, «Enseñanza y aprendizaje académico en el nexo: desagregación, mercantilización y digitalización en la educación superior,» Teaching in Higher Education, vol. 26, nº 2021, p. 16, 2021. [3]S. Dogan y A. Adam, «Aumentar el efecto del desarrollo profesional en la instrucción efectiva a través de comunidades profesionales,» Docentes y docencia: teoría y práctica, vol. 26, nº 3-4, pp. 326-349, 2020. [4]I. M. Torres Salas, «La enseñanza tradicional de las ciencias versus las nuevas tendencias educativas,» Educare, vol. 14, nº 1, pp. 131-142, 2010. [5]B. Fabio, J. Antonio Palomino y J. González Henríquez, «Evaluación y contraste de los métodos de enseñanza tradicional y lúdico,» Revista de Educación física y deportes, vol. 13, nº 94, pp. 29-36, 2008. [6]Y. Benítez y C. Mora, «Enseñanza tradicional vs aprendizaje activo,» Revista Cubana de Física, vol. 27, nº 2A, pp. 175-179, 2010. [7]P. Morales Bueno y V. Landa Fitzgerald, «Aprendizaje basado en problemas,» Theoria, vol. 13, nº 1, pp. 145-157, 2004. [8]R. Gil-Galván, I. Martín-Espinosa y F. Gil-Galván, «University student perceptions of competences acquired through problem-based learning,» Educación XXI, vol. 24, nº 1, pp. 271-295, 2020. [9]E. Ortiz Cermeño, «El aprendizaje basado en problemas,» Perfiles Educativos, vol. 41, nº 164, pp. 208-213, 2019. [10]E. Araos-Baeriswyl, C. Moll-Manzur, Á. Paredes y J. Landeros, «Aprendizaje invertido: un enfoque pedagógico en tiempos de pandemia,» Rev. Atención Primaria, vol. 53, nº 1, p. 117, 2021. [11]V. León-Carrascosa, M. Belando-Montoro y S. Sánchez-Serrano, «Design and validation of a questionnaire to evaluate the service-learning methodology,» Rev.Estudios sobre educación, vol. 39, nº 1, pp. 247-266, 2020. [12]J. Collado-Ruano, M. Ojeda, M. Malo y D. Amino, «Educación, arte e interculturalidad: El cine documental como lenguaje comunicativo y tecnología innovadora para el aprendizaje de la metodología I + D + I,» Rev. Texto livre, vol. 13, nº 3, pp. 376-393, 2020. [13]P. M. Bueno y V. Landa Fitzgerald, «Aprendizaje basado en problemas,» Theoria, vol. 13, nº 1, pp. 145-157, 2004. [14]J. A. Martí, M. Heydrich, M. Rojas y A. Hernández, «Aprendizaje basado en proyectos: Una experiencia de innovación docente,» Universidad EAFIT, vol. 46, nº 158, pp. 11-21, 2010. [15]L. Rojas y N. M. Jaimes, «Canvas LMS y el trabajo colaborativo como metodología de aprendizaje en entornos virtuales,» de Congreso Ibérico de Sistemas y Tecnologías de la Información, CISTI, Bogotá, Colombia, 2020. [16]B. Bordel y P. Mareca, «Results and Trends in educational MOOCs in the engineering area with MIRIADAX platform. A case study,» de 15th Iberian Conference on Information Systems and Technologies, CISTI 2020; Seville; Sevilla, España, 2020. [17]K. Vermeir y G. Kelchtermans, «Innovative practice as interpretative negotiation.A case-study on the kamishibai in Kindergarten.,» Teachers and Teaching: Theory and Practice, vol. 26, nº 3-4, pp. 248-263, 2020. [18]B. Tucker, «The Flipped Classroom: Online instruction at home frees class time for learning,» Education Next, vol. 1, nº 1, pp. 82-84, 2012. [19]M. V. Ledo, N. R. Michelena, N. N. Cao, I. d. R. M. Suárez y M. N. Vialart Vidal, « Aula invertida, nueva estrategia didáctica,» Educación Médica Superior, vol. 30, nº 3, pp. 678-688, 2016. [20]Metodologías activas por medio de las TIC, [Online]. Available: https://www.campuseducacion.com/blog/recursos/articulos-campuseducacion metodologias-activas-por-medio-de-las-tic/?cn-reloaded=1. [Last access: February 14, 2021]. (shrink)

Los intereses del ingeniero y filósofo chileno Manuel Atria Ramírez recorren una variedad de temas y disciplinas, pero es en la filosofía de las matemáticas y de la física donde se centra una porción importante de su obra publicada. Tras una primera fase de juventud, de manifiesta impronta tomista, su pensamiento de madurez acusa el influjo de las grandes escuelas epistemológicas que prosperan durante la primera mitad del siglo XX. Además de ilustrar la recepción que se le daba por aquellos (...) años en el medio académico latinoamericano a las nuevas tendencias filosóficas europeas, pensamos que el conciso estilo expositivo del autor y su comprensión profunda de la físico-matemática y de su historia, tienen el mérito de plantear con frescura y originalidad la pregunta referida al fundamento último de las matemáticas, y de su vinculación con la realidad. En este artículo presentamos y analizamos las principales directrices de la propuesta epistemológica de Atria, e identificamos algunos puntos abiertos a investigaciones ulteriores. (shrink)

There has been an intense discussion, albeit largely an implicit one, concerning the inference of causal hypotheses from statistical correlations in quantum mechanics ever since John Bell’s first statement of his notorious theorem in 1966. As is well known, its focus has mainly been the so-called Einstein-Podolsky-Rosen (“EPR”) thought experiment, and the ensuing observed correlations in real EPR like experiments. But although implicitly the discussion goes as far back as Bell’s work, it is only in the last two decades that (...) it has become recognizably and explicitly a debate about causal inference in the quantum realm. The bulk of this paper is devoted to a review of three influential arguments in the philosophical literature that aim to show that causal models for the EPR correlations are impossible, due to Bas Van Fraassen, Daniel Hausman and Huw Price. I contend that all these arguments are inconclusive since they contain premises or presuppositions that are false, unwarranted, or at least controversial. Five different common cause models are outlined that seem perfectly viable for the EPR correlations. These models are then employed to illustrate various difficulties with the premises and presuppositions underlying Van Fraassen’s, Hausman’s and Price’s arguments. In all these cases it is argued that the difficulties cut deep against these authors’ own theories of causation and causal inference. My conclusions are that causal models for the EPR correlations remain viable, that philosophical work is still required to assess their relative virtues, and that in any case the mere theoretical conceivability and empirical possibility of these models sheds doubts over Van Fraassen’s, Hausman’s and (important elements in) Price’s theories of causation and causal inference. (shrink)

Journal of Social Philosophy, Volume 53, Issue 1, Page 38-58, Spring 2022.

To design and develop AI-based cybersecurity systems ), users can justifiably trust, one needs to evaluate the impact of trust using machine learning and deep learning technologies. To guide the design and implementation of trusted AI-based systems in IDS, this paper provides a comparison among machine learning and deep learning models to investigate the trust impact based on the accuracy of the trusted AI-based systems regarding the malicious data in IDs. The four machine learning techniques are decision tree, K nearest (...) neighbour, random forest, and naïve Bayes. The four deep learning techniques are LSTM and GRU. Two datasets are used to classify the IDS attack type, including wireless sensor network detection system and KDD Cup network intrusion dataset. A detailed comparison of the eight techniques’ performance using all features and selected features is made by measuring the accuracy, precision, recall, and F1-score. Considering the findings related to the data, methodology, and expert accountability, interpretability for AI-based solutions also becomes demanded to enhance trust in the IDS. (shrink)

ArgumentThis paper explores the connection between the epistemic and the “political” dimensions of the metaphor of information during the early days of the study of Molecular Evolution. While preserving some of the meanings already documented in the history of molecular biology, the metaphor acquired a new, powerful use as a substitute for “history.” A rhetorical analysis of Emilé Zuckerkandl's paper, “Molecules as Documents of Evolutionary History,” highlights the ways in which epistemic claims on the validity and superiority of molecular evidence (...) for evolution were intimately connected with authority issues in evolutionary biology. The debate is situated within the framework of the battle for resources between traditional evolutionists and molecular biologists at the beginning of the 1960s. The architects of evolutionary synthesis questioned the idea that molecular characters constitute “cleaner” and “more direct” evidence of evolution. Nevertheless, the information discourse constituted a productive space for the development of a new research program that, paradoxically, has made explicit the limitations of the information metaphor in reconstructing life's history. (shrink)

El estudio aborda cómo perciben un grupo de estudiantes de Grado de Educación Infantil la fase de seducción en el cortejo heterosexual en la actualidad. Este estudio forma parte de una investigación en la que se preguntaba a futuros docentes por películas determinantes que trabajarían en el aula. Las películas mostraron estereotipos sexistas y mitos del amor romántico. El estudio explora si los discursos con los que se narra la seducción comparten las representaciones del amor romántico.

In the last three decades, ongoing debates on the epistemic features of democratic decision making have influenced the way we conceive the basic terms of democratic theory, such as inclusion, participation, public reason, and collective autonomy.1 Within these debates, attention has been given to the role played by mobilized collectives in the generation of the knowledge necessary for the enhancement of the epistemic quality of those processes. However, little attention has been given to a further epistemic function of mobilizations: the (...) innovations they have brought about in the very practices within which new knowledge and perspectives are generated. Using... (shrink)

This volume defends a novel approach to the philosophy of physics: it is the first book devoted to a comparative study of probability, causality, and propensity, and their various interrelations, within the context of contemporary physics -- particularly quantum and statistical physics. The philosophical debates and distinctions are firmly grounded upon examples from actual physics, thus exemplifying a robustly empiricist approach. The essays, by both prominent scholars in the field and promising young researchers, constitute a pioneer effort in bringing out (...) the connections between probabilistic, causal and dispositional aspects of the quantum domain. The book will appeal to specialists in philosophy and foundations of physics, philosophy of science in general, metaphysics, ontology of physics theories, and philosophy of probability. (shrink)

This is an introductory essay to the symposium on Michael Friedman’s The Dynamics of Reason. It provides a summary description of the symposium and its rationale; an introduction to Michael Friedman’s views on the a priori and what it refers to as ‘developmental Kantianism’; a summary of the content of each of the four contributed papers in the symposium; and a philosophical analysis of the symposium as a whole in relation with developmental Kantianism.

En este artículo analizaré algunos puntos de convergencia entre la filosofía transhumanista y la crítica filosófica contemporánea al antropocentrismo. Para ello distinguiré entre un tipo de programa normativo fuerte y uno débil en el transhumanismo. El argumento central reside en que la normatividad fuerte en el discurso transhumanista, al suponer que es posible seleccionar exclusivamente las características “propiamente humanas” para ser conservadas en el estadio post-humano, se basa en una concepción pre-darwiniana de la especie humana, lo cual posee implicancias tanto (...) epistemológicas como éticas. (shrink)

This paper is divided in two parts. In part I, I argue against two attempts to naturalise the notion of scientific representation, by reducing it to isomorphism and similarity. I distinguish between the means and the constituents of representation, and I argue that isomorphism and similarity are common means of representation; but that they are not constituents of scientific representation. I look at the prospects for weakened versions of these theories, and I argue that only those that abandon the aim (...) to naturalise scientific representation are likely to be successful. In part II of the paper, I present a deflationary conception of scientific representation, which minimally characterises it by means of two necessary conditions: representation is essentially intentional and it has the capacity to allow surrogate reasoning and inference. I then defend this conception by showing that it successfully meets the objections and difficulties that make its competitors, such as isomorphism and similarity, untenable. In addition the inferential conception explains the success of various means of representation in their appropriate domains, and it sheds light on the truth and accuracy of scientific representations. (shrink)

En este trabajo se intentan mostrar algunas tensiones entre el discurso de la conservación, el multiculturalismo y los prejuicios racistas, tomando como punto de referencia el caso de los Montes de María en el Caribe colombiano, donde han tenido lugar proyectos de cooperación a propósito de la biodiversidad y existen iniciativas locales para su conservación. Se describen tres niveles en los que pueden encontrarse los prejuicios racistas en el discurso de la conservación, y las tensiones que los caracterizan, asociadas tanto (...) a las ideas de resistencia y de comunidad, como a la necesidad de corrección de las prácticas por parte de quienes habitan los bosques. El propósito de estas reflexiones es cuestionar el discurso de la conservación y el multiculturalismo para ampliar las perspectivas frente a las apuestas por la conservación y las luchas étnico-campesinas que se llevan a cabo en la alta montaña de los Montes de María, similares seguramente a otros casos en América Latina. (shrink)

In the present study, we have demonstrated hysteresis phenomena in the excitability of single, enzymatically dissociated guinea pig ventricular myocytes. Membrane potentials were recorded with patch pipettes in the whole-cell current clamp configuration. Repetitive stimulation with depolarizing current pulses of constant cycle length and duration but varying strength led to predictable excitation (1:l) and non-excitation (1:0) patterns depending on current strength. In addition, transition between patterns depended on the direction of current intensity change and stable hysteresis loops were obtained in (...) stimulus:response pattern vs. current intensity plots in 14 cells. Increase of pulse duration and decrease of stimulation rate contributed to a reduction in hysteresis loop areas. Changes in amplitude and shape of the subthreshold responses during the transitions from one stable pattern to the other, suggested that activity led to an increase in membrane resistance, particularly in the voltage domain between resting potential, and threshold. Therefore, we modelled the dynamic behaviour of the single cells as a function of diastolic membrane resistance, using previously published analytical solutions. Numerical iteration of the analytical model equations closely reproduced the experimental hysteresis loops in both qualitative and quantitative ways. In particular, the effect of stimulation frequency on the model was similar to the experimental findings. The overall study suggests that the excitability pattern of guinea pig ventricular myocytes accounts for hysteresis and bistabilities when current intensity is allowed to fluctuate around threshold levels. (shrink)

El artículo considera la obra de Fichte a partir de la noción de nihilismo, interpretándola sobre todo como una subordinación de la vida afectiva al imperativo moral. Tras su salida de Jena, Fichte habría intentado responder a las críticas de Jacobi, convirtiendo el concepto de vida en un tema central de su filosofía. El intento de conciliar esa dependencia del imperativo moral y la importancia dada a la vida a partir de las objeciones de Jacobi, permitiría entender algunas claves de (...) su filosofía en el periodo de Berlín y en particular su concepción de lo absoluto. (shrink)